Literature summary extracted from

Kraus, E.; Kiltz, H.H.; Femfert, U.F.
The specificity of proteinase K against oxidized insulin B chain (1976), Hoppe-Seyler's Z. Physiol. Chem., 357, 233-237.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.21.64	extracellular	-	Parengyodontium album	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.64	Parengyodontium album	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.64	culture filtrate	-	Parengyodontium album	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.64	additional information	the smallest peptide hydrolyzable should be a tetrapeptide, so that the enzyme could be used as an appropriate tool for sequence analysis of medium size peptides	Parengyodontium album	?	-	?
3.4.21.64	Oxidized insulin B-chain + H2O	main cleavage sites: Gln4-His5, Ser9-His10, Leu11-Val12, Leu15-Tyr16, Leu17-Val18, Phe24-Phe25, Tyr26-Thr27	Parengyodontium album	Hydrolyzed oxidized insulin B-chain	main cleavage sites: Gln4-His5, Ser9-His10, Leu11-Val12, Leu15-Tyr16, Leu17-Val18, Phe24-Phe25, Tyr26-Thr27	?

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Release 2023.1 (January 2023)